Chemotherapy helps in halting the progress of cancer spreading in the body. Unfortunately, it even impacts the normal blood cells including hair follicles, reproductive system, bone marrow cells, and mouth cells. Research has recommended that CBD [extract from cannabis plant] can help in treating the chemotherapy’s side effects.
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How CBD works on chemotherapy side effects?
Reduces cisplatin-induced nephrotoxicity
Renal tissue has toxins present in your body due to prescription drugs, which causes nephrotoxicity. The toxins badly impact kidney functioning. Cisplatin is an antineoplastic drug used to treat cancers in the breast, testis, ovary, head, neck, and lung. In excess, cisplatin can cause allergic reactions, ototoxicity, and gastrotoxicity. Even if you adhere to the recommended dose, its side effect is nephrotoxicity. It exhibits acute kidney injury in several patients.
In Chemotherapy routines, cisplatin is frequently administered, which increases the nephrotoxicity levels. CBD is anti-inflammatory and can help in dampening nephrotoxicity severity caused due to chemotherapy side effects from cisplatin.
Decreases nausea & vomiting
Emetic reflex gets stimulated, which triggers acute vomiting to remove the underlying cause. Antineoplastic drugs employed in chemotherapy can have a devastating impact on cancer patients. Vomiting is a defense response triggered due to several brain receptors. It includes dopamine, serotonin, and opioid receptors. Serotonin receptors of the nervous system irritate the GI mucosa.
Neuropeptide called substance P gets released and it activates NK1 receptors that cause vomiting. A study has revealed that phytocannabinoid CBD possesses anti-nausea and antiemetic properties that can ease the chemotherapy routines for cancer patients. CBD activates the somatodendritic receptors in the brain indirectly and suppresses the feeling of nausea & vomiting.
Relieves from chemotherapy-induced neuropathic pain
There can be episodic or chronic pain due to disease or damage affecting the somatosensory nerves. Neuropathic pain can also include coldness or burning, itching, and numbness due to disorder in the central or peripheral nervous system.
Anticancer drugs can cause side effects like a deficit in motor, automatic, and sensory functions. There is a need for medicines that lower neuropathic pain for cancer patients to continue their chemotherapy comfortably.
A study found that CBD helped to get relieved from chemotherapy-induced neuropathic pain without any concerns about compromising the ability of the drug to fight breast cancer.
Lessens chemotherapy-induced swelling
When an exorbitant amount of fluid accumulates beneath your skin and body cavities, it swells and the condition is termed Oedema. Swelling is the result of body inflammation that leads to excessive fluid secretion. Internal swelling is a sign of serious damage or side effect of drugs.
Oedema and swelling are mainly due to blood vessel inflammation or kidney failure. Chemotherapy-induced swelling is due to cancer medication. Chemotherapy drugs can cause hormonal change, kidney failure, and excessive fluid retention.
Even cancer can cause hyper-secretion of internal fluid and apply an inflammatory response. Anti-inflammatory drugs are prescribed for chemotherapy side-effect treatment. Recently, CBD products are used to relieve cancer patients from chemotherapy-induced swelling.
